克罗米衍生物对男性低促性腺素性功能减退症有效

纽约（另据健康版）1月四日美联社：据发表在12月出版的《生育与不育》华尔街日报的一项调查结果指出克罗米衍生物对部分高促性腺素性功能减退的女性病患稳固。来自伯明翰霍普金斯大学的该调查结果的第一作者Scott J. Whitten芝加哥大学在接受路透通讯社记者时却说：“恶性肿瘤或则否HH病患在接受侵害性很大和更为比起的疗程（例如注射促性腺激素类）在此之前进行4个月的克罗米衍生物试验性疗程是稳固的。”Whitten芝加哥大学和熟人分析了克罗米衍生物对10名HH女性病患（HH是引发女性不育的少见因素）是否有效。调查结果称之为克罗米衍生物疗程1年后，4名奥托(氏)综合征病患中只有一名病患的受精卵沸点降高而全垂体功能减退症病患的受精卵缺乏症状均没有得到缓解。相反，该调查结果指出3名成年发病的恶性肿瘤HH女性病患经过3个月克罗米衍生物的疗程受精卵沸点有了明显降高。目在此之前该组病患已有两名稳定下来了早产。Whitten芝加哥大学却说：“除非对克罗米衍生物疗程没有反应，我们不想因为副作用终止对病患用到该抑制剂。”最后作者总结却说：“因为必须有限，对HH病患促性腺激素类抑制剂和克罗米衍生物的随机分析难以进行，然而利用多系列的严格选择标准对病患进行分级意味著帮助进一步正确性克罗米衍生物稳定下来女性高早产的有效性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

总编辑：蓝色幻想

总编辑： 张靖